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http://purl.uniprot.org/citations/16352682http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16352682http://www.w3.org/2000/01/rdf-schema#comment"

Context

Nephrolithiasis affects about 10% of the population in industrialized countries, with calcium salts composing more than 80% of renal stones. A significant percentage of patients with calcium nephrolithiasis and normal parathyroid function show hypophosphatemia and reduced renal phosphate reabsorption (i.e. a renal phosphate leak).

Objectives

The objective of the study was to compare serum levels of fibroblast growth factor 23 (FGF23), a regulator of phosphate homeostasis, in 110 recurrent stone formers with or without renal phosphate leak, six patients affected by X-linked hypophosphatemic rickets, five patients affected by oncogenic osteomalacia, and 60 unrelated healthy controls.

Design

This was a prospective interventional study.

Methods

Renal phosphate leak was identified based on the occurrence of idiopathic hypophosphatemia [serum phosphate concentration < 2.50 mg/dl (<0.80 mmol/liter)] and reduced renal threshold phosphate concentration [<2.2 mg/liter (<0.70 mmol/liter)].

Results

In 22 stone formers with renal phosphate leak, serum FGF23 concentration was significantly higher as compared with 88 stone formers without renal phosphate leak and with controls [83.3 (65.6-101.1) vs. 32.1 (26.8-37.4) and 24.5 (19.8-29.1) reference units (RU)/ml, respectively]. Stone formers with renal phosphate leak showed lower FGF23, compared with patients with oncogenic osteomalacia and X-linked hypophosphatemic rickets [572.3 (235.9-908.7) RU/ml]. Among stone formers and controls, serum FGF23 concentration displayed a strong inverse association with serum phosphate (r = -0.784, P = 0.009) and the rate of tubular phosphate reabsorption (r = -0.791, P = 0.008).

Conclusions

In our study population, renal phosphate leak affected 20% of stone formers and was strongly associated with increased serum FGF23 concentration."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.org/dc/terms/identifier"doi:10.1210/jc.2005-1606"xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/author"Cioffi M."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/author"Strazzullo P."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/author"De Filippo G."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/author"Rendina D."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/author"Mossetti G."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/pages"959-963"xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/title"Fibroblast growth factor 23 is increased in calcium nephrolithiasis with hypophosphatemia and renal phosphate leak."xsd:string
http://purl.uniprot.org/citations/16352682http://purl.uniprot.org/core/volume"91"xsd:string
http://purl.uniprot.org/citations/16352682http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16352682
http://purl.uniprot.org/citations/16352682http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16352682
http://purl.uniprot.org/uniprot/#_Q9GZV9-mappedCitation-16352682http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16352682
http://purl.uniprot.org/uniprot/#_Q7Z4T2-mappedCitation-16352682http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16352682
http://purl.uniprot.org/uniprot/Q9GZV9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16352682
http://purl.uniprot.org/uniprot/Q7Z4T2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16352682