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http://purl.uniprot.org/citations/16352685http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16352685http://www.w3.org/2000/01/rdf-schema#comment"

Context

Transracial studies are a powerful tool for genetic association studies of multifactorial diseases, such as type 1 diabetes. The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia.

Objective

To overcome this, we have assembled a multicenter study group in Japan and studied the association of CTLA4 polymorphisms with type 1 diabetes relative to autoimmune thyroid disease (AITD) phenotypes.

Subjects

Subjects included a total of 1837 samples, including 1114 cases (769 with type 1 diabetes and 345 with AITD) and 723 control subjects.

Methods

The +6230G>A and +49G>A polymorphisms of CTLA4 as well as HLA-DRB1 and -DQB1 were genotyped.

Results

The +6230G>A polymorphism was significantly associated with type 1 diabetes complicated with AITD (odds ratio, 1.54; P = 0.027) and with AITD alone (odds ratio, 1.31; P = 0.045) but not with type 1 diabetes without AITD. The association with type 1 diabetes positive for autoantibodies to both pancreatic islets and thyroid was particularly strong (odds ratio, 1.87; P = 0.001). Type 1 diabetic patients with the disease-associated GG genotype were characterized by a significantly higher frequency of AITD (P = 0.013), of positivity for both AITD and antiislet autoantibody (P = 0.00086), and of high-risk HLA genotypes (P = 0.034).

Conclusions

Given the high frequency of AITD in patients with type 1 diabetes, these data suggest the possibility that the association of CTLA4 with type 1 diabetes in previous studies may have been secondary to AITD, suggesting the importance of subclassification of type 1 diabetes relative to AITD in genetic studies."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.org/dc/terms/identifier"doi:10.1210/jc.2005-1407"xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Kobayashi T."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Maruyama T."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Mochizuki M."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Ogihara T."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Tanaka S."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Shimada A."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Nakanishi K."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Awata T."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Ikegami H."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Kurihara S."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Kanazawa Y."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Kawasaki E."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Kawabata Y."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/author"Amemiya S."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/pages"1087-1092"xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/title"The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan."xsd:string
http://purl.uniprot.org/citations/16352685http://purl.uniprot.org/core/volume"91"xsd:string
http://purl.uniprot.org/citations/16352685http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16352685
http://purl.uniprot.org/citations/16352685http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16352685
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-16352685http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16352685
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