| http://purl.uniprot.org/citations/16352737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16352737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16352737 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide synthase 2A, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein-1alpha genes in tuberculosis patients and healthy controls from Mexico. The odds of developing tuberculosis were 2.3- and 5.4-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Cases of homozygous GG had the highest plasma levels of MCP-1 and the lowest plasma levels of IL-12p40, and these values were negatively correlated. Furthermore, stimulation of monocytes from healthy carriers of the genotype GG with Mycobacterium tuberculosis antigens yielded higher MCP-1 and lower IL-12p40 concentrations than parallel experiments with monocytes from homozygous AA. Addition of anti-MCP-1 increased IL-12p40 levels in cultures of M. tuberculosis-stimulated monocytes from homozygous GG, and addition of exogenous MCP-1 reduced IL-12p40 production by M. tuberculosis-stimulated monocytes from homozygous AA. Furthermore, we could replicate our results in Korean subjects, in whom the odds of developing tuberculosis were 2.8- and 6.9-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Our findings suggest that persons bearing the MCP-1 genotype GG produce high concentrations of MCP-1, which inhibits production of IL-12p40 in response to M. tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050126"xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050126"xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Montano M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Montano M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Barnes P.F."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Barnes P.F."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Flores L.M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Flores L.M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Flores-Villanueva P.O."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Flores-Villanueva P.O."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Granados J."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Granados J."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Jo E.-K."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Jo E.-K."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Ruiz-Morales J.A."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Ruiz-Morales J.A."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Selman M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Selman M."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Song C.-H."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/author | "Song C.-H."xsd:string |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16352737 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |