| http://purl.uniprot.org/citations/16354700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16354700 | http://www.w3.org/2000/01/rdf-schema#comment | "TRPV5 and TRPV6 are the most Ca2+-selective members of the transient receptor potential (TRP) family of cation channels and play a pivotal role in the maintenance of Ca2+ balance in the body. However, little is known about the mechanisms controlling the plasma membrane abundance of these channels to regulate epithelial Ca2+ transport. In this study, we demonstrated the direct and specific interaction of GDP-bound Rab11a with TRPV5 and TRPV6. Rab11a colocalized with TRPV5 and TRPV6 in vesicular structures underlying the apical plasma membrane of Ca2+-transporting epithelial cells. This GTPase recognized a conserved stretch in the carboxyl terminus of TRPV5 that is essential for channel trafficking. Furthermore, coexpression of GDP-locked Rab11a with TRPV5 or TRPV6 resulted in significantly decreased Ca2+ uptake, caused by diminished channel cell surface expression. Together, our data demonstrated the important role of Rab11a in the trafficking of TRPV5 and TRPV6. Rab11a exerts this function in a novel fashion, since it operates via direct cargo interaction while in the GDP-bound configuration."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.1.303-312.2006"xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/author | "Bindels R.J."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/author | "Hoenderop J.G."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/author | "van de Graaf S.F."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/author | "Chang Q."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/author | "Mensenkamp A.R."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/pages | "303-312"xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/title | "Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16354700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16354700 |
| http://purl.uniprot.org/citations/16354700 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16354700 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW69-mappedCitation-16354700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16354700 |
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| http://purl.uniprot.org/uniprot/#_E9Q3P9-mappedCitation-16354700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16354700 |
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