| http://purl.uniprot.org/citations/16357171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16357171 | http://www.w3.org/2000/01/rdf-schema#comment | "Nr-CAM, a cell-cell adhesion molecule of the immunoglobulin-like cell adhesion molecule family, known for its function in neuronal outgrowth and guidance, was recently identified as a target gene of beta-catenin signaling in human melanoma and colon carcinoma cells and tissue. Retrovirally mediated transduction of Nr-CAM into fibroblasts induces cell motility and tumorigenesis. We investigated the mechanisms by which Nr-CAM can confer properties related to tumor cell behavior and found that Nr-CAM expression in NIH3T3 cells protects cells from apoptosis in the absence of serum by constitutively activating the extracellular signal-regulated kinase and AKT signaling pathways. We detected a metalloprotease-mediated shedding of Nr-CAM into the culture medium of cells transfected with Nr-CAM, and of endogenous Nr-CAM in B16 melanoma cells. Conditioned medium and purified Nr-CAM-Fc fusion protein both enhanced cell motility, proliferation, and extracellular signal-regulated kinase and AKT activation. Moreover, Nr-CAM was found in complex with alpha4beta1 integrins in melanoma cells, indicating that it can mediate, in addition to homophilic cell-cell adhesion, heterophilic adhesion with extracellular matrix receptors. Suppression of Nr-CAM levels by small interfering RNA in B16 melanoma inhibited the adhesive and tumorigenic capacities of these cells. Stable expression of the Nr-CAM ectodomain in NIH3T3 cells conferred cell transformation and tumorigenesis in mice, suggesting that the metalloprotease-mediated shedding of Nr-CAM is a principal route for promoting oncogenesis by Nr-CAM."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-2647"xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Sakurai T."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Kaplan A."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Conacci-Sorrell M."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Raveh S."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/author | "Gavert N."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/pages | "11605-11612"xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/title | "The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation."xsd:string |
| http://purl.uniprot.org/citations/16357171 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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