| http://purl.uniprot.org/citations/16357362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16357362 | http://www.w3.org/2000/01/rdf-schema#comment | "Caveolin-1 has been reported to regulate apoptosis, lipid metabolism, and endocytosis in macrophages. In the present study, we demonstrate that caveolin-1 can act as a potent immunomodulatory molecule. We first observed caveolin-1 expression in murine alveolar macrophages by Western blotting and immunofluorescence microscopy. Loss-of-function experiments using small interfering RNA showed that down regulating caveolin-1 expression in murine alveolar and peritoneal macrophages increased LPS-induced proinflammatory cytokine TNF-alpha and IL-6 production but decreased anti-inflammatory cytokine IL-10 production. Gain-of-function experiments demonstrated that overexpression of caveolin-1 in RAW264.7 cells decreased LPS-induced TNF-alpha and IL-6 production and augmented IL-10 production. p38 mitogen-activated protein kinase (MAPK) phosphorylation was increased by overexpressing caveolin-1 in RAW264.7 cells, whereas c-Jun N-terminal kinase, extracellular signal-regulated kinase MAPK, and Akt phosphorylation were inhibited. The antiinflammatory modulation of LPS-induced cytokine production by caveolin-1 was significantly abrogated by the administration of p38 inhibitor SB203580 in RAW264.7 cells. Peritoneal macrophages isolated from MKK3 null mice did not demonstrate any modulation of LPS-induced cytokine production by caveolin-1. LPS-induced activation of NF-kappaB and AP-1 determined by electrophoretic mobility shift assay were significantly reduced by overexpressing caveolin-1 in RAW264.7 cells. The reductions were attenuated by the administration of p38 inhibitor SB203580. Taken together, our data suggest that caveolin-1 acts as a potent immunomodulatory effector molecule in immune cells and that the regulation of LPS-induced cytokine production by caveolin-1 involves the MKK3/p38 MAPK pathway."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2005-0376oc"xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/author | "Song R."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/author | "Wang X.M."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/author | "Kim H.P."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/author | "Choi A.M."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/pages | "434-442"xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/title | "Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway."xsd:string |
| http://purl.uniprot.org/citations/16357362 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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