| http://purl.uniprot.org/citations/16357871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16357871 | http://www.w3.org/2000/01/rdf-schema#comment | "How a cell chooses to proliferate or to differentiate is an important issue in stem cell and cancer biology. Drosophila neuroblasts undergo self-renewal with every cell division, producing another neuroblast and a differentiating daughter cell, but the mechanisms controlling the self-renewal/differentiation decision are poorly understood. Here we tested whether cell polarity genes, known to regulate embryonic neuroblast asymmetric cell division, also regulate neuroblast self-renewal. Clonal analysis in larval brains showed that pins mutant neuroblasts rapidly fail to self-renew, whereas lethal giant larvae (lgl) mutant neuroblasts generate multiple neuroblasts. Notably, lgl pins double mutant neuroblasts all divide symmetrically to self-renew, filling the brain with neuroblasts at the expense of neurons. The lgl pins neuroblasts show ectopic cortical localization of atypical protein kinase C (aPKC), and a decrease in aPKC expression reduces neuroblast numbers, suggesting that aPKC promotes neuroblast self-renewal. In support of this hypothesis, neuroblast-specific overexpression of membrane-targeted aPKC, but not a kinase-dead version, induces ectopic neuroblast self-renewal. We conclude that cortical aPKC kinase activity is a potent inducer of neuroblast self-renewal."xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04299"xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/author | "Lee C.Y."xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/author | "Doe C.Q."xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/author | "Robinson K.J."xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/pages | "594-598"xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/title | "Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation."xsd:string |
| http://purl.uniprot.org/citations/16357871 | http://purl.uniprot.org/core/volume | "439"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ6-mappedCitation-16357871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16357871 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-16357871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16357871 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ8-mappedCitation-16357871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16357871 |
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| http://purl.uniprot.org/uniprot/#_O44224-mappedCitation-16357871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16357871 |