| http://purl.uniprot.org/citations/16360037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16360037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16360037 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of NF-kappaB following genotoxic stress allows time for DNA-damage repair and ensures cell survival accounting for acquired chemoresistance, an impediment to effective cancer therapy. Despite this clinical relevance, little is known about pathways that enable genotoxic-stress-induced NF-kappaB induction. Previously, we reported a role for the p53-inducible death-domain-containing protein, PIDD, in caspase-2 activation and apoptosis in response to DNA damage. We now demonstrate that PIDD plays a critical role in DNA-damage-induced NF-kappaB activation. Upon genotoxic stress, a complex between PIDD, the kinase RIP1, and a component of the NF-kappaB-activating kinase complex, NEMO, is formed. PIDD expression enhances genotoxic-stress-induced NF-kappaB activation through augmented sumoylation and ubiquitination of NEMO. Depletion of PIDD and RIP1, but not caspase-2, abrogates DNA-damage-induced NEMO modification and NF-kappaB activation. We propose that PIDD acts as a molecular switch, controlling the balance between life and death upon DNA damage."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.09.036"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.09.036"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/pages | "1079-1092"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/pages | "1079-1092"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/title | "PIDD mediates NF-kappaB activation in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/title | "PIDD mediates NF-kappaB activation in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/16360037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16360037 |
| http://purl.uniprot.org/citations/16360037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16360037 |