| http://purl.uniprot.org/citations/16362036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16362036 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids dramatically inhibit cytokine and chemokine production. They act through the glucocorticoid receptor (GR), a ligand-dependent transcription factor that binds to and represses activities of other DNA-bound regulators, activator protein 1 and nuclear factor kappaB, utilizing a p160 GRIP1 as a corepressor. A yeast two-hybrid screen with the GRIP1 corepression domain (RD) yielded interferon (IFN) regulatory factor (IRF)3-a downstream effector of Toll-like receptors (TLR) 3/4 and an essential activator of several IFN and chemokine genes. We defined the GRIP1:IRF3 interface and showed that endogenous GRIP1 and IRF3 interact in mammalian cells. Interestingly, GR and IRF3 competed for GRIP1 binding; GR activation or GRIP1 knockdown in macrophages blocked whereas GRIP1 overexpression rescued IRF3-dependent gene expression. GR interference persisted in MyD88- and IFNA receptor-deficient mice, suggesting a specific disruption of TLR3-IRF3 pathway, not of autocrine IFN signaling. Finally, IRF3-stimulated response elements were necessary and sufficient for TLR3-dependent induction and glucocorticoid inhibition. Thus, GRIP1 plays a cofactor role in innate immunity. Competition with GR for GRIP1 antagonizes IRF3-mediated transcription, identifying the GRIP1:IRF3 interaction as a novel target for glucocorticoid immunosuppression."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600919"xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/author | "Pantoja C."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/author | "Rogatsky I."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/author | "Chinenov Y."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/author | "Reily M.M."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/pages | "108-117"xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/title | "The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression."xsd:string |
| http://purl.uniprot.org/citations/16362036 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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