| http://purl.uniprot.org/citations/16364187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16364187 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell receptor (TCR) engagement initiates intracellular signalling cascades that lead to T-cell proliferation, cytokine production and differentiation into effector cells. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions. The integration of these signals is essential for the normal development, homeostasis and function of T cells. Defects in a single mediator can produce T cells that are unable to participate fully in an immune response and/or that mount an inappropriate response, which leads to immunodeficiency, autoimmunity or leukaemia/lymphomas. This review highlights some of the key players in T-cell signalling and their involvement in the development of various clinical disease states. Some of these immune-specific signalling proteins are attractive potential targets in the development of therapies to augment T-cell responses to antigen or tumours, and to treat immune cell disorders."xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.org/dc/terms/identifier | "doi:10.1017/s1462399405010264"xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/author | "Wilkinson B."xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/author | "Downey J.S."xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/name | "Expert Rev Mol Med"xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/pages | "1-29"xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/title | "T-cell signalling and immune system disorders."xsd:string |
| http://purl.uniprot.org/citations/16364187 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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