| http://purl.uniprot.org/citations/16365160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16365160 | http://www.w3.org/2000/01/rdf-schema#comment | "Keratins 8 and 18 (K8/18) are major constituents of Mallory bodies (MBs), which are hepatocyte cytoplasmic inclusions seen in several liver diseases. K18-null but not K8-null or heterozygous mice form MBs, which indicates that K8 is important for MB formation. Early stages in MB genesis include K8/18 hyperphosphorylation and overexpression. We used transgenic mice that overexpress K8, K18, or K8/18 to test the importance of K8 and/or K18 in MB formation. MBs were induced by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). Livers of young K8 or K8/K18 overexpressors had no histological abnormalities despite increased keratin protein and phosphorylation. In aging mice, only K8-overexpressing livers spontaneously developed small "pre-MB" aggregates. Only K8-overexpressing young mice are highly susceptible to MB formation after short-term DDC feeding. Thus, the K8 to K18 ratio, rather than K8/18 overexpression by itself, plays an essential role in MB formation. K8 overexpression is sufficient to form pre-MB and primes animals to accumulate MBs upon DDC challenge, which may help explain MB formation in human liver diseases."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200507093"xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Toivola D.M."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Omary M.B."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Oshima R.G."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Strnad P."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Baribault H."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Michie S.A."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/author | "Nakamichi I."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/pages | "931-937"xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/title | "Keratin 8 overexpression promotes mouse Mallory body formation."xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/16365160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16365160 |
| http://purl.uniprot.org/citations/16365160 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16365160 |
| http://purl.uniprot.org/uniprot/#_P11679-mappedCitation-16365160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365160 |
| http://purl.uniprot.org/uniprot/#_Q78EH3-mappedCitation-16365160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365160 |
| http://purl.uniprot.org/uniprot/P11679 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16365160 |
| http://purl.uniprot.org/uniprot/Q78EH3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16365160 |