| http://purl.uniprot.org/citations/16365394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16365394 | http://www.w3.org/2000/01/rdf-schema#comment | "The recently identified CXCL16 has dual functions as a transmembrane adhesion molecule and a soluble chemokine. In this study we found that CXCL16 mRNA and protein were expressed constitutively on the follicle-associated epithelium covering Peyer's patches (PPs), isolated lymphoid follicles, and cecal patches, but minimally on the villous epithelium in the murine gastrointestinal tract. The CXCL16 receptor CXCR6/Bonzo was constitutively expressed on subpopulations of CD4+ and CD8+ T cells isolated from PPs. The expression of CXCR6/Bonzo on the PP T cells was up-regulated after stimulation with anti-CD3 and anti-CD28 mAbs. The activated PP T cells showed chemotactic migration in response to the soluble N-terminal chemokine domain of CXCL16. Furthermore, the activated PP T cells selectively adhered to cells expressing murine CXCL16. To determine the physiological role of CXCL16 in GALT, we first carefully analyzed T cell distribution in PPs. T cells localized not only in the interfollicular region but also at a lesser frequency in the subepithelial dome (SED) and in the germinal center of lymphoid follicles. Consistently, the majority of the adoptive transferred activated T cells migrated into the SED and the interfollicular region. However, the neutralization of CXCL16 specifically reduced the migration of the adoptive, transferred, activated T cells into the SED of PPs. These data suggest that CXCL16 expressed on the follicle-associated epithelium plays an important role in the recruitment and retention of activated T cells in the SED and should, at least partially, be responsible for lymphocyte compartmentalization in GALT."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.1.43"xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Itoh K."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Kawano K."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Murakami T."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Yonehara S."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Hase K."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Takatsu H."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Shimaoka T."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Ohshima S."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Hamura K."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Iimura M."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/author | "Chihara R."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/pages | "43-51"xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/title | "The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT."xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16365394 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16365394 |
| http://purl.uniprot.org/citations/16365394 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16365394 |
| http://purl.uniprot.org/uniprot/#_A2CFE9-mappedCitation-16365394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365394 |
| http://purl.uniprot.org/uniprot/#_D9YM45-mappedCitation-16365394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365394 |
| http://purl.uniprot.org/uniprot/#_I7HIQ2-mappedCitation-16365394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365394 |