| http://purl.uniprot.org/citations/16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16365422 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell aging manifests itself both at the cellular (cell-autonomous defects in signaling) and at the population (age-related dysregulation of T cell homeostasis) levels. A prominent contributor to the latter is the appearance of T cell clonal expansions (TCE), with a potential to impair immune defense. In this study, we investigated molecular, cellular, and Ag requirements for TCE development. Of the mutant mice tested, old animals lacking MHC class I exhibited 7-fold fewer TCE than controls, with a 7-fold reduction in TCE. By contrast, animals lacking only one of the MHC class I molecules (Kb or Db), or IL-7R, or devoid of T cell renewal via adult thymectomy, all exhibited significant increases in TCE incidence. This increase directly correlated to lymphopenia, increased CD8 T cell turnover and an accumulation of memory-phenotype T cells. These data suggested that homeostatic cell division in the CD8 compartment enhances the formation of TCE. Repeated immunization with peptide/adjuvant did not result in an increase in Ag-specific TCE; however, adjuvant alone increased TCE incidence. In these experiments, therefore, nonspecific and/or homeostatic proliferation was more efficient in generating TCE in mice than repeated Ag-driven stimulation, suggesting that many, if not most, TCE in specific pathogen-free laboratory mice may be Ag-independent."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.1.301"xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/author | "Warner J."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/author | "Messaoudi I."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/author | "Nikolich-Zugich J."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/author | "Nikolich-Zugich D."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/pages | "301-308"xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/title | "Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo."xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16365422 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16365422 |
| http://purl.uniprot.org/citations/16365422 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |
| http://purl.uniprot.org/uniprot/#_A0A494BA33-mappedCitation-16365422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365422 |