| http://purl.uniprot.org/citations/16365431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16365431 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways. In the present study, STAP-2 was found to positively regulate LPS/TLR4-mediated signals in macrophages. Disruption of STAP-2 resulted in impaired LPS/TLR4-induced cytokine production and NF-kappaB activation. Conversely, overexpression of STAP-2 enhanced these LPS/TLR4-induced biological activities. STAP-2, particularly its Src homology 2-like domain, bound to both MyD88 and IkappaB kinase (IKK)-alphabeta, but not TNFR-associated factor 6 or IL-1R-associated kinase 1, and formed a functional complex composed of MyD88-STAP-2-IKK-alphabeta. These interactions augmented MyD88-and/or IKK-alphabeta-dependent signals, leading to enhancement of the NF-kappaB activity. These results demonstrate that STAP-2 may constitute an alternative LPS/TLR4 pathway for NF-kappaB activation instead of the TNFR-associated factor 6-IL-1R-associated kinase 1 pathway."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.1.380"xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Shimoda K."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Minoguchi M."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Yumioka T."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/author | "Sugiyma K."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/pages | "380-389"xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/title | "Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages."xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16365431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16365431 |
| http://purl.uniprot.org/citations/16365431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16365431 |
| http://purl.uniprot.org/uniprot/#_O15111-mappedCitation-16365431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365431 |
| http://purl.uniprot.org/uniprot/#_P25963-mappedCitation-16365431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365431 |
| http://purl.uniprot.org/uniprot/#_O14920-mappedCitation-16365431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16365431 |