| http://purl.uniprot.org/citations/16368182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16368182 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the ubiquitin/proteasome system in degrading nuclear hormone receptors and regulating their transcriptional function has emerged in the last few years. We identified the ubiquitin-specific protease USP10 as part of DNA-bound androgen receptor (AR) complexes purified from nuclear extracts of PC-3 cells stably expressing the AR. The interaction between USP10 and the AR was confirmed by GST pull-down assays. Fluorescence microscopy documented that USP10 was localised in the nucleus and the cytoplasm. Cell-based transactivation assays in PC-3/AR cells revealed that overexpression of wild-type USP10, but not of an enzymatically inactive form, stimulated AR activity mediated by reporter constructs harbouring selective androgen response elements (AREs), non-selective steroid response elements (SREs) or the mouse mammary tumour virus (MMTV) promoter. Conversely, USP10 expression knock-down by siRNAs impaired the MMTV response to androgen. In summary, the data indicate that USP10 is a new cofactor that binds to the AR and stimulates the androgen response of target promoters. This finding underlines the role of the ubiquitin/proteasome system in modulating the AR function."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2005.11.011"xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/author | "Huber M."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/author | "Haendler B."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/author | "Meyer H.A."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/author | "Bahr I."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/author | "Faus H."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/pages | "138-146"xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/title | "The ubiquitin-specific protease USP10 modulates androgen receptor function."xsd:string |
| http://purl.uniprot.org/citations/16368182 | http://purl.uniprot.org/core/volume | "245"xsd:string |
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