| http://purl.uniprot.org/citations/16371131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16371131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16371131 | http://www.w3.org/2000/01/rdf-schema#comment | "N regions at the junction of V, D and J DNA segments are synthesized with large protein complexes including terminal deoxynucleotidyltransferase (TdT) during V(D)J recombination in B- or T-cells. TdT directly binds to TdIF1, TdIF2, PCNA and the Ku70/86 heterodimer. Using a yeast two-hybrid system, we isolated a cDNA clone encoding the gene for TReP-132, which is involved in P450scc gene expression in steroid-hormone-producing cells or lymphoid cells. Interaction between TReP-132 and TdIF1 was confirmed by pull-down assay and immunoprecipitation assay using specific antibodies against TReP-132 both in vitro and in vivo. TdT also directly bound to TReP-132 through its confined N-terminal region. Furthermore, the co-expression of TdIF1 and TReP-132 or TdT and TReP-132 in COS7 cells showed that these proteins are co-localized within the nucleus. TReP-132 reduces TdT activity to 2.5% of its maximum value in the in vitro assay system using double-stranded DNA with a 3' protrusion as a primer. These findings suggest that TdT synthesizes N region under a negative control of TReP-132 during V(D)J recombination."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2005.00916.x"xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2005.00916.x"xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Fujisaki S."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Fujisaki S."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Sato A."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Sato A."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Sugai M."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Sugai M."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Koiwai O."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Koiwai O."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Hayano T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Hayano T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Toyomoto T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/author | "Toyomoto T."xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/pages | "47-57"xsd:string |
| http://purl.uniprot.org/citations/16371131 | http://purl.uniprot.org/core/pages | "47-57"xsd:string |