| http://purl.uniprot.org/citations/16371134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16371134 | http://www.w3.org/2000/01/rdf-schema#comment | "The presenilin (PS) complex, including PS, nicastrin (NCT), APH-1 and PEN-2, is essential for gamma-secretase activity. Previously, the PS C-terminal tail was shown to be essential for gamma-secretase activity. Here, to further understand the precise mechanism underlying the activation of gamma-secretase regulated by PS cofactors, we focused on the role of the PS1 C-terminal region including transmembrane domain (TM) 8 in gamma-secretase activity. For this purpose, we co-expressed C-terminally truncated PS1 (PS1DeltaC) completely lacking gamma-secretase activity and the PS1 C-terminal short fragment in PS-null cells, because the successful reconstitution of gamma-secretase activity in PS-null cells by the co-expression of PS1DeltaC and the PS1 C-terminal short fragment would allow us to investigate the role of the PS1 C-terminal region in gamma-secretase activity. We found that the exogenous expression of the PS1 C-terminal short fragment with NCT and APH-1 completely rescued a defect of the gamma-secretase activity of PS1DeltaC in PS-null cells. With this reconstitution system, we demonstrate that both TM8 and the PS1 C-terminal seven-amino-acid-residue tail are involved in the formation of the active gamma-secretase complex via the assembly of PS1 with NCT and APH-1."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2005.00914.x"xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Maeda Y."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Yanagisawa K."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Shiraishi H."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Araki W."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Takashima A."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Komano H."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Wang H.Q."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Kurono Y."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/author | "Marutani T."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/pages | "83-93"xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/title | "Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex."xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/16371134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16371134 |
| http://purl.uniprot.org/citations/16371134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16371134 |
| http://purl.uniprot.org/uniprot/Q8C7N7#attribution-08E77D52AB3089AD8FD9ED779D0639DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16371134 |
| http://purl.uniprot.org/uniprot/Q8C7N7#attribution-CE384898462BF46BA61BA2A9E43AF063 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16371134 |
| http://purl.uniprot.org/uniprot/P57716#attribution-08E77D52AB3089AD8FD9ED779D0639DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16371134 |
| http://purl.uniprot.org/uniprot/P57716#attribution-CE384898462BF46BA61BA2A9E43AF063 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16371134 |
| http://purl.uniprot.org/uniprot/Q9CQR7#attribution-CE384898462BF46BA61BA2A9E43AF063 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16371134 |