| http://purl.uniprot.org/citations/16373427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16373427 | http://www.w3.org/2000/01/rdf-schema#comment | "Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction between COX and NOS isoforms during healing are less clear. Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in COX-1 and COX-2 deficiency and inhibition mouse models. In this study, female wild-type COX-1(-/-) and COX-2(-/-) mice with gastric ulcers induced by cryoprobe were treated intragastrically with vehicle, selective COX-1 (SC-560), COX-2 (celecoxib, rofecoxib, and valdedoxib), and unselective COX (piroxicam) inhibitors. Ulcer healing parameters, mRNA expression, and activity of COX and NOS were quantified. Gene disruption or inhibition of COX-1 did not impair ulcer healing. In contrast, COX-2 gene disruption and COX-2 inhibitors moderately impaired wound healing. More severe healing impairment was found in dual (SC-560 + rofecoxib) and unselective (piroxicam) COX inhibition and combined COX impairment (in COX-1(-/-) mice with COX-2 inhibition and COX-2(-/-) mice with COX-1 inhibition). In the ulcerated repair tissue, COX-2 mRNA in COX-1(-/-) mice, COX-1 mRNA in COX-2(-/-) mice, and, remarkably, NOS-2 and NOS-3 mRNA in COX-impaired mice were more upregulated than in wild-type mice. This study demonstrates that COX-2 is a key mediator in gastric wound healing. In contrast, COX-1 has no significant role in healing when COX-2 is unimpaired but becomes important when COX-2 is impaired. As counterregulatory mechanisms, mRNA of COX and NOS isoforms were increased during healing in COX-impaired mice."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00416.2005"xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Zoidl G."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Schmassmann A."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Reubi J.C."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Waser B."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Gebbers J.O."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Peskar B.M."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/author | "Schmassmann-Suhijar D."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/pages | "G747-56"xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/title | "Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/16373427 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16373427 |
| http://purl.uniprot.org/citations/16373427 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16373427 |
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| http://purl.uniprot.org/uniprot/#_A0A286YDF6-mappedCitation-16373427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16373427 |
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| http://purl.uniprot.org/uniprot/#_Q64494-mappedCitation-16373427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16373427 |