| http://purl.uniprot.org/citations/16373657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16373657 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the relationship between granulocyte JAK2 (V617F) mutation status, circulating CD34(+) cells, and granulocyte activation in myeloproliferative disorders. Quantitative allele-specific polymerase chain reaction (PCR) showed significant differences between various disorders with respect to either the proportion of positive patients (53%-100%) or that of mutant alleles, which overall ranged from 1% to 100%. In polycythemia vera, JAK2 (V617F) was detected in 23 of 25 subjects at diagnosis and in 16 of 16 patients whose disease had evolved into myelofibrosis; median percentages of mutant alleles in these subgroups were significantly different (32% versus 95%, P < .001). Circulating CD34(+) cell counts were variably elevated and associated with disease category and JAK2 (V617F) mutation status. Most patients had granulocyte activation patterns similar to those induced by administration of granulocyte colony-stimulating factor. A JAK2 (V617F) gene dosage effect on both CD34(+) cell counts and granulocyte activation was clearly demonstrated in polycythemia vera, where abnormal patterns were mainly found in patients carrying more than 50% mutant alleles. These observations suggest that JAK2 (V617F) may constitutively activate granulocytes and by this means mobilize CD34(+) cells. This exemplifies a novel paradigm in which a somatic gain-of-function mutation is initially responsible for clonal expansion of hematopoietic cells and later for their abnormal trafficking via an activated cell progeny."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-09-3826"xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Cazzola M."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Della Porta M.G."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Malcovati L."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Pascutto C."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Pietra D."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Rumi E."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Lazzarino M."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Passamonti F."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Arcaini L."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Boveri E."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Burcheri S."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/author | "Vanelli L."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/pages | "3676-3682"xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/title | "Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders."xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/16373657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16373657 |
| http://purl.uniprot.org/citations/16373657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16373657 |
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| http://purl.uniprot.org/uniprot/#_A8K910-mappedCitation-16373657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16373657 |
| http://purl.uniprot.org/uniprot/#_B4DYV1-mappedCitation-16373657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16373657 |