| http://purl.uniprot.org/citations/16374507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16374507 | http://www.w3.org/2000/01/rdf-schema#comment | "A central function of telomeres is to prevent chromosome ends from being recognized as DNA double-strand breaks (DSBs). Several proteins involved in processing DSBs associate with telomeres, but the roles of these factors at telomeres are largely unknown. To investigate whether the Mre11/Rad50/Nbs1 (MRN) complex is involved in the generation of proper 3' G-overhangs at human telomere ends, we used RNA interference to decrease expression of MRN and analysed their effects. Reduction of MRN resulted in a transient shortening of G-overhang length in telomerase-positive cells. The terminal nucleotides of both C- and G-rich strands remain unaltered in Mre11-diminished cells, indicating that MRN is not responsible for specifying the final end-processing event. The reduction in overhang length was not seen in telomerase-negative cells, but was observed after the expression of exogenous telomerase, which suggested that the MRN complex might be involved in the recruitment or action of telomerase."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400600"xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/author | "Chai W."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/author | "Shay J.W."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/author | "Wright W.E."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/author | "Hoshiyama H."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/author | "Sfeir A.J."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/pages | "225-230"xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/title | "The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres."xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16374507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16374507 |
| http://purl.uniprot.org/citations/16374507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16374507 |
| http://purl.uniprot.org/uniprot/P49959#attribution-4BA06B0F261EDC286CB7FAD0906FFFFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16374507 |
| http://purl.uniprot.org/uniprot/O60934#attribution-4BA06B0F261EDC286CB7FAD0906FFFFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16374507 |
| http://purl.uniprot.org/uniprot/Q92878#attribution-4BA06B0F261EDC286CB7FAD0906FFFFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16374507 |