| http://purl.uniprot.org/citations/16376880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16376880 | http://www.w3.org/2000/01/rdf-schema#comment | "The HBx protein of hepatitis B virus is involved in deregulation of cell cycle and development of hepatocellular carcinoma. Since c-Myc also plays an important role in cell proliferation and tumor development, we studied its regulation by HBx in a human hepatoma cell line. Co-expression of HBx and c-Myc resulted in increased stability of intracellular c-Myc. HBx blocked the ubiquitination of Myc through a direct interaction with the F box region of Skp2 and destabilization of the SCF(Skp2) complex. We suggest that sustained presence of c-Myc combined with mitogenic activity inherent to HBx may be associated with cell cycle deregulation and transformation."xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.12.034"xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/author | "Kalra N."xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/pages | "431-436"xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/title | "The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc."xsd:string |
| http://purl.uniprot.org/citations/16376880 | http://purl.uniprot.org/core/volume | "580"xsd:string |
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