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| http://purl.uniprot.org/citations/16377571 | http://www.w3.org/2000/01/rdf-schema#comment | "Cortical polarity regulates cell division, migration, and differentiation. Microtubules induce cortical polarity in yeast, but few examples are known in metazoans. We show that astral microtubules, kinesin Khc-73, and Discs large (Dlg) induce cortical polarization of Pins/Galphai in Drosophila neuroblasts; this cortical domain is functional for generating spindle asymmetry, daughter-cell-size asymmetry, and distinct sibling fates. Khc-73 localizes to astral microtubule plus ends, and Dlg/Khc-73 and Dlg/Pins coimmunoprecipitate, suggesting that microtubules induce Pins/Galphai cortical polarity through Dlg/Khc-73 interactions. The microtubule/Khc-73/Dlg pathway acts in parallel to the well-characterized Inscuteable/Par pathway, but each provides unique spatial and temporal information: The Inscuteable/Par pathway initiates at prophase to coordinate neuroblast cortical polarity with CNS tissue polarity, whereas the microtubule/Khc-73/Dlg pathway functions at metaphase to coordinate neuroblast cortical polarity with the mitotic spindle axis. These results identify a role for microtubules in polarizing the neuroblast cortex, a fundamental step for generating cell diversity through asymmetric cell division."xsd:string |
| http://purl.uniprot.org/citations/16377571 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.09.043"xsd:string |
| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/author | "Doe C.Q."xsd:string |
| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/author | "Siegrist S.E."xsd:string |
| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
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| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/title | "Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/16377571 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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