| http://purl.uniprot.org/citations/16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16380094 | http://www.w3.org/2000/01/rdf-schema#comment | "Although caveolin-1 is not expressed in cardiomyocytes, this protein is assumed to act as a key regulator in the development of cardiomyopathy. In view of recent discordant findings we aimed to elucidate the cardiac phenotype of independently generated caveolin-1 knockout mice (cav-1(-/-)) and to unveil causative mechanisms. Invasive hemodynamic measurements of cav-1(-/-) show a severely reduced systolic and diastolic heart function. Additionally, genetic ablation of caveolin-1 leads to a striking biventricular hypertrophy and to a sustained eNOS-hyperactivation yielding increased systemic NO levels. Furthermore, a diminished ATP content and reduced levels of cyclic AMP in hearts of knockout animals were measured. Taken together, these results indicate that genetic disruption of caveolin-1 is sufficient to induce a severe biventricular hypertrophy with signs of systolic and diastolic heart failure. Collectively, our findings suggest a causative role of a sustained nitrosative stress in the development of the pronounced cardiac impairment."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.12.058"xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Wunderlich C."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Braun-Dullaeus R.C."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Schmeisser A."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Strasser R.H."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Kasper M."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Drab M."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Schwencke C."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Lange S.A."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/author | "Schober K."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/pages | "702-708"xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/title | "Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure."xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/16380094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16380094 |
| http://purl.uniprot.org/citations/16380094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16380094 |
| http://purl.uniprot.org/uniprot/P49817#attribution-04882DBEAF423722DB7FEED14A6A38FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16380094 |
| http://purl.uniprot.org/uniprot/#_D3Z0J2-mappedCitation-16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380094 |
| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380094 |
| http://purl.uniprot.org/uniprot/#_H3BLQ4-mappedCitation-16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380094 |
| http://purl.uniprot.org/uniprot/#_H3BKG0-mappedCitation-16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380094 |
| http://purl.uniprot.org/uniprot/#_P49817-mappedCitation-16380094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380094 |