| http://purl.uniprot.org/citations/16380437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16380437 | http://www.w3.org/2000/01/rdf-schema#comment | "p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53(-/-) mice display a high bone mass phenotype, and p53(-/-) osteoblasts show accelerated differentiation, secondary to an increase in expression of the osteoblast differentiation factor osterix, as a result. Reporter assays indicate that p53 represses osterix transcription by the minimal promoter in a DNA-binding-independent manner. In addition, p53(-/-) osteoblasts have an enhanced ability to favor osteoclast differentiation, in association with an increase in expression of macrophage-colony stimulating factor, which is under the control of osterix. Furthermore, inactivating p53 is sufficient to rescue the osteoblast differentiation defects observed in mice lacking c-Abl, a p53-interacting protein. Thus, these results identify p53 as a novel regulator of osteoblast differentiation, osteoblast-dependent osteoclastogenesis, and bone remodeling."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200507106"xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Guo K."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "de Crombrugghe B."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Karsenty G."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Ng H.H."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Yeh J."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/author | "Kua H.Y."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/pages | "115-125"xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/title | "p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling."xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/16380437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16380437 |
| http://purl.uniprot.org/citations/16380437 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16380437 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVY6-mappedCitation-16380437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380437 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXS9-mappedCitation-16380437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380437 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY65-mappedCitation-16380437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380437 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-16380437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16380437 |