| http://purl.uniprot.org/citations/16388914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16388914 | http://www.w3.org/2000/01/rdf-schema#comment | "To complete a series of studies on the expression of substance P and neurokinin receptors in mammalian retinas, we investigated the occurrence of these molecules in developing mouse retinas and in retinas of mice with genetic deletion of the neurokinin 1 receptor, the preferred substance P receptor. Using semi-quantitative reverse transcription-polymerase chain reaction, we measured detectable levels of the gamma isoform of preprotachykinin A (a substance P precursor) mRNA at postnatal day 4. Neurokinin 1 receptor and neurokinin 3 receptor mRNAs were also detected at postnatal day 4. While gamma preprotachykinin A and neurokinin 1 receptor mRNA levels significantly increased up to eye opening (postnatal day 11), neurokinin 3 receptor mRNA levels remained constant throughout development. Substance P, neurokinin 1 receptor and neurokinin 3 receptor immunoreactivities were present at postnatal day 5. Substance P was in amacrine cells, neurokinin 1 receptor in developing amacrine and bipolar cells and neurokinin 3 receptor in OFF-type cone bipolar cells. Interestingly, a transient increase in the density of neurokinin 1 receptor immunoreactive processes was observed at eye opening in lamina 3 of the inner plexiform layer, suggesting a role of substance P and neurokinin 1 receptor in this developmental phase. However, in neurokinin 1 receptor knockout retinas, besides a significant increase of the gamma preprotachykinin A mRNA levels, no major changes were detected: neurokinin 3 receptor mRNA levels as well as substance P and neurokinin 3 receptor immunostainings were similar to wild types. Together with previous studies, these observations indicate that there are major differences in neurokinin 1 receptor expression patterns among developing mammalian retinas. The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2005.11.020"xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Fineschi S."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Casini G."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Dal Monte M."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Bosco L."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Bagnoli P."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Catalani E."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Gangitano C."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/author | "Lucattelli M."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/pages | "487-499"xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/title | "Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/16388914 | http://purl.uniprot.org/core/volume | "138"xsd:string |
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