| http://purl.uniprot.org/citations/16391015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16391015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16391015 | http://www.w3.org/2000/01/rdf-schema#comment | "Minor histocompatibility antigens (mHAg's) are peptides encoded by polymorphic genes that are presented by major histocompatibility complex (MHC) molecules and recognized by T cells in recipients of allogeneic hematopoietic cell transplants. Here we report that an alternative transcript of the proliferation-associated nuclear element 1 (PANE1) gene encodes a novel human leukocyte antigen (HLA)-A(*)0301-restricted mHAg that is selectively expressed in B-lymphoid cells. The antigenic peptide is entirely encoded within a unique exon not present in other PANE1 transcripts. Sequencing of PANE1 alleles in mHAg-positive and mHAg-negative cells demonstrates that differential T-cell recognition is due to a single nucleotide polymorphism within the variant exon that replaces an arginine codon with a translation termination codon. The PANE1 transcript that encodes the mHAg is expressed at high levels in resting CD19(+) B cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells, and at significantly lower levels in activated B cells. Activation of B-CLL cells through CD40 ligand (CD40L) stimulation decreases expression of the mHAg-encoding PANE1 transcript and reciprocally increases expression of PANE1 transcripts lacking the mHAg-encoding exon. These studies suggest distinct roles for different PANE1 isoforms in resting compared with activated CD19(+) cells, and identify PANE1 as a potential therapeutic target in B-CLL."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-08-3501"xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-08-3501"xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Hunt D.F."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Hunt D.F."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Shabanowitz J."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Shabanowitz J."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Nishida T."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Nishida T."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Riddell S.R."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Riddell S.R."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Ferrell R.E."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Ferrell R.E."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Brickner A.G."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Brickner A.G."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Engelhard V.H."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Engelhard V.H."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Evans A.M."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Evans A.M."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Fairfull L."xsd:string |
| http://purl.uniprot.org/citations/16391015 | http://purl.uniprot.org/core/author | "Fairfull L."xsd:string |