| http://purl.uniprot.org/citations/16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407120 | http://www.w3.org/2000/01/rdf-schema#comment | "The ATR (ATM- and rad3-related)-mediated checkpoint pathway has a crucial role in regulating the cellular responses to DNA damage and DNA-replication stress. ATRIP (ATR-interacting protein), the regulatory partner of ATR, binds directly to replication protein A (RPA)-coated ssDNA and enables the ATR-ATRIP complex to recognize this DNA damage-induced structure. Here, we show that ATRIP associates with RPA-ssDNA through multiple interactions. Two major RPA-ssDNA-interacting domains of ATRIP were mapped to the regions flanking the conserved coiled-coil domain. In contrast to a recent article, we found that ATRIP mutants lacking the N terminus retained the ability to bind to RPA-ssDNA, suggesting that the multiple interactions between ATRIP and RPA-ssDNA may function redundantly in the recruitment of ATR-ATRIP. Unexpectedly, one internal region of ATRIP exhibited affinity to ssDNA, suggesting that ATRIP may interact with ssDNA in the ATRIP-RPA-ssDNA complex. Also, the N terminus of ATRIP associated with RPA-ssDNA in two distinct ways, indicating a dynamic and regulated association between ATRIP and RPA-ssDNA."xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0510223103"xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/author | "Zou L."xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/author | "Namiki Y."xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/pages | "580-585"xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/title | "ATRIP associates with replication protein A-coated ssDNA through multiple interactions."xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16407120 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16407120 |
| http://purl.uniprot.org/citations/16407120 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16407120 |
| http://purl.uniprot.org/uniprot/#_Q13535-mappedCitation-16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/#_P15927-mappedCitation-16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/#_P27694-mappedCitation-16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/#_P35244-mappedCitation-16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/#_Q8WXE1-mappedCitation-16407120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/P27694 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/P35244 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/Q13535 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/Q8WXE1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16407120 |
| http://purl.uniprot.org/uniprot/P15927 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16407120 |