| http://purl.uniprot.org/citations/16407282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407282 | http://www.w3.org/2000/01/rdf-schema#comment | "Specific cell type differentiation is driven by programmed regulation of gene expression, which is the result of coordinated modulation of the transcription machinery and chromatin-remodeling factors. We present evidence here that the down-regulation of histone deacetylases is an important process during adipocyte differentiation. In 3T3-L1 cells, histone hyperacetylation was selectively induced at the promoter regions of adipogenic genes during adipocyte differentiation. Interestingly, this was accompanied by a dramatic decrease in the expression level of several histone deacetylases including HDAC1, -2, and -5 and a reduction in overall histone deacetylase enzyme activity. Inhibition of histone deacetylase activity using sodium butyrate resulted in stimulation of adipogenic gene expression and adipocyte differentiation. Consistently, HDAC1 knock-down promoted adipogenesis whereas HDAC1 overexpression attenuated adipocyte differentiation in 3T3-L1 cells. Together, these results suggest that the regulation of not only adipogenic transcription factors, but also chromatin-modifying enzymes is crucial for the execution of bona fide adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508982200"xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/author | "Kim J.B."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/author | "Choe S.S."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/author | "Yoo E.J."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/author | "Chung J.J."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/pages | "6608-6615"xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/title | "Down-regulation of histone deacetylases stimulates adipocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16407282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16407282 |
| http://purl.uniprot.org/citations/16407282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16407282 |
| http://purl.uniprot.org/uniprot/#_Q15528-mappedCitation-16407282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407282 |
| http://purl.uniprot.org/uniprot/#_Q15596-mappedCitation-16407282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407282 |
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| http://purl.uniprot.org/uniprot/#_B7ZDF7-mappedCitation-16407282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407282 |
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