| http://purl.uniprot.org/citations/16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407283 | http://www.w3.org/2000/01/rdf-schema#comment | "The superoxide-generating phagocytic NADPH oxidase is an important component of the innate immune response against microbial agents, and is involved in shaping the cellular response to a variety of physiological and pathological signals. One of the downstream targets of NADPH oxidase-derived radicals is the ubiquitous transcription factor NF-kappaB, which controls the expression of a large array of genes involved in immune function and cell survival. Here we show that NF-kappaB itself is a key factor in controlling NADPH oxidase expression and function. In monocytic and microglial cell lines, the expression of the NADPH oxidase subunit gp91(phox) was induced by lipopolysaccharide/interferon gamma treatment and was inhibited in cells constitutively expressing IkappaBalpha. Furthermore, inducible reactive oxygen species production was inhibited in IkappaBalpha overexpressing cells. gp91(phox) expression was very low in RelA(-/-) fibroblasts and could be induced by reconstituting these cells with p65/RelA. Thus, gp91(phox) expression is dependent on the presence of p65/RelA. We also found that gp91(phox) transcription is dependent on NF-kappaB and we identified two potential cis-acting elements in the murine gp91(phox) promoter that control NF-kappaB-dependent regulation. The findings raise the possibility of a positive feedback loop in which NF-kappaB activation by oxidative stress leads to further radical production via NADPH oxidase."xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m506172200"xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/author | "Anrather J."xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/author | "Iadecola C."xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/author | "Racchumi G."xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/pages | "5657-5667"xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/title | "NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox."xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16407283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16407283 |
| http://purl.uniprot.org/citations/16407283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16407283 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q3U4P0-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q2TAM5-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q04206-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q13313-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q3TVP4-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q61093-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q3U6G0-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |
| http://purl.uniprot.org/uniprot/#_Q3U6M7-mappedCitation-16407283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16407283 |