| http://purl.uniprot.org/citations/16407407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407407 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria consist of four compartments-outer membrane, intermembrane space, inner membrane, and matrix--with crucial but distinct functions for numerous cellular processes. A comprehensive characterization of the proteome of an individual mitochondrial compartment has not been reported so far. We used a eukaryotic model organism, the yeast Saccharomyces cerevisiae, to determine the proteome of highly purified mitochondrial outer membranes. We obtained a coverage of approximately 85% based on the known outer membrane proteins. The proteome represents a rich source for the analysis of new functions of the outer membrane, including the yeast homologue (Hfd1/Ymr110c) of the human protein causing Sjögren-Larsson syndrome. Surprisingly, a subclass of proteins known to reside in internal mitochondrial compartments were found in the outer membrane proteome. These seemingly mislocalized proteins included most top scorers of a recent genome-wide analysis for mRNAs that were targeted to mitochondria and coded for proteins of prokaryotic origin. Together with the enrichment of the precursor form of a matrix protein in the outer membrane, we conclude that the mitochondrial outer membrane not only contains resident proteins but also accumulates a conserved subclass of preproteins destined for internal mitochondrial compartments."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-08-0740"xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-08-0740"xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Zahedi R.P."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Zahedi R.P."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Sickmann A."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Sickmann A."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Guiard B."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Guiard B."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Meisinger C."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Meisinger C."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Pfanner N."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Pfanner N."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Schoenfisch B."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Schoenfisch B."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Winkler C."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Winkler C."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Boehm A.M."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Boehm A.M."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Zufall N."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/author | "Zufall N."xsd:string |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407407 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |