| http://purl.uniprot.org/citations/16407410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16407410 | http://www.w3.org/2000/01/rdf-schema#comment | "The tight junction adaptor protein ZO-1 regulates intracellular signaling and cell proliferation. Its Src homology 3 (SH3) domain is required for the regulation of proliferation and binds to the Y-box transcription factor ZO-1-associated nucleic acid binding protein (ZONAB). Binding of ZO-1 to ZONAB results in cytoplasmic sequestration and hence inhibition of ZONAB's transcriptional activity. Here, we identify a new binding partner of the SH3 domain that modulates ZO-1-ZONAB signaling. Expression screening of a cDNA library with a fusion protein containing the SH3 domain yielded a cDNA coding for Apg-2, a member of the heat-shock protein 110 (Hsp 110) subfamily of Hsp70 heat-shock proteins, which is overexpressed in carcinomas. Regulated depletion of Apg-2 in Madin-Darby canine kidney cells inhibits G(1)/S phase progression. Apg-2 coimmunoprecipitates with ZO-1 and partially localizes to intercellular junctions. Junctional recruitment and coimmunoprecipitation with ZO-1 are stimulated by heat shock. Apg-2 competes with ZONAB for binding to the SH3 domain in vitro and regulates ZONAB's transcriptional activity in reporter gene assays. Our data hence support a model in which Apg-2 regulates ZONAB function by competing for binding to the SH3 domain of ZO-1 and suggest that Apg-2 functions as a regulator of ZO-1-ZONAB signaling in epithelial cells in response to cellular stress."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-06-0507"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-06-0507"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Balda M.S."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Balda M.S."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Matter K."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Matter K."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Tsapara A."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/author | "Tsapara A."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/pages | "1322-1330"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/pages | "1322-1330"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/title | "The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/title | "The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB."xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/16407410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16407410 |
| http://purl.uniprot.org/citations/16407410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16407410 |
| http://purl.uniprot.org/citations/16407410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16407410 |
| http://purl.uniprot.org/citations/16407410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16407410 |