| http://purl.uniprot.org/citations/16410793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16410793 | http://www.w3.org/2000/01/rdf-schema#comment | "Death receptors in the TNF receptor superfamily signal for apoptosis via the ordered recruitment of FADD and caspase-8 to a death-inducing signaling complex (DISC). However, the nature of the protein-protein interactions in the signaling complex is not well defined. Here we show that FADD self-associates through a conserved RXDLL motif in the death effector domain (DED). Despite exhibiting similar binding to both Fas and caspase-8 and preserved overall secondary structure, FADD RDXLL motif mutants cannot reconstitute FasL- or TRAIL-induced apoptosis and fail to recruit caspase-8 into the DISC of reconstituted FADD-deficient cells. Abolishing self-association can transform FADD into a dominant-negative mutant that interferes with Fas-induced apoptosis and formation of microscopically visible receptor oligomers. These findings suggest that lateral interactions among adapter molecules are required for death receptor apoptosis signaling and implicate self-association into oligomeric assemblies as a key function of death receptor adapter proteins in initiating apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401855"xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Yang J.K."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Siegel R.M."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Ramaswamy M."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Lobito A.A."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/author | "Muppidi J.R."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/pages | "1641-1650"xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/title | "Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16410793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16410793 |
| http://purl.uniprot.org/citations/16410793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16410793 |
| http://purl.uniprot.org/uniprot/#_B4DDS8-mappedCitation-16410793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16410793 |
| http://purl.uniprot.org/uniprot/#_Q13158-mappedCitation-16410793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16410793 |
| http://purl.uniprot.org/uniprot/#_Q6LCG1-mappedCitation-16410793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16410793 |
| http://purl.uniprot.org/uniprot/#_Q6LCB0-mappedCitation-16410793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16410793 |
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| http://purl.uniprot.org/uniprot/B4DDS8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16410793 |
| http://purl.uniprot.org/uniprot/Q6LCG1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16410793 |
| http://purl.uniprot.org/uniprot/Q13158 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16410793 |