| http://purl.uniprot.org/citations/16410805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16410805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16410805 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFN-alpha/-beta) are capable of suppressing c-myc mRNA expression by modulating post-transcriptional processing. However, the molecular mechanism of this phenomenon is poorly understood. We previously established that human polynucleotide phosphorylase (hPNPase(old-35)), a type I IFN-inducible 3',5' exoribonuclease involved in mRNA degradation, induces G1 cell cycle arrest and eventually apoptosis by specifically degrading c-myc mRNA. We now demonstrate a close association between IFN-beta-induced hPNPase(old-35) upregulation and c-myc downregulation in human melanoma cells. Employing stable melanoma cell clones expressing hPNPase(old-35) small inhibitory RNA, we demonstrate that hPNPase(old-35) is a key molecule coupled with IFN-beta-mediated downregulation of c-myc mRNA. Inhibition of hPNPase(old-35) or overexpression of c-myc protects melanoma cells from IFN-beta-mediated growth inhibition, emphasizing the importance of hPNPase(old-35) upregulation and consequent c-myc downregulation in IFN-beta-induced growth inhibition and apoptosis induction. In these contexts, targeted overexpression of hPNPase(old-35) might be a novel therapeutic strategy for c-myc-overexpressing and IFN-resistant tumors, such as melanomas."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401829"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401829"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Park E.S."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/author | "Park E.S."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/pages | "1541-1553"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/pages | "1541-1553"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/title | "Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/title | "Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)."xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16410805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16410805 |
| http://purl.uniprot.org/citations/16410805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16410805 |
| http://purl.uniprot.org/citations/16410805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16410805 |
| http://purl.uniprot.org/citations/16410805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16410805 |