| http://purl.uniprot.org/citations/16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16413178 | http://www.w3.org/2000/01/rdf-schema#comment | "The interactions of cells with basement membranes are primarily mediated via the engagement of laminins by a group of integrin family proteins, including integrins alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4. To explore the ligand-binding specificities of these laminin-binding integrins, we produced these integrins, including two alpha7beta1 splice variants (alpha7X1beta1 and alpha7X2beta1), as soluble recombinant proteins and determined their binding specificities and affinities toward a panel of purified laminin isoforms containing distinct alpha chains. Among the five laminin-binding integrins investigated, alpha3beta1 and alpha6beta4 exhibited a clear specificity for laminin-332 (alpha3beta3gamma2) and laminin-511 (alpha5beta1gamma1)/521 (alpha5beta2gamma1), while integrin alpha6beta1 showed a broad specificity, binding to all laminin isoforms with a preference for laminin-111 (alpha1beta1gamma1), laminin-332 and laminin-511/521. The two alpha7beta1 variants were distinct from alpha3beta1, alpha6beta1 and alpha6beta4 in that they did not bind to laminin-332. alpha7X1beta1 bound to all laminins, except laminin-332, with a preference for laminin-211 (alpha2beta1gamma1)/221 (alpha2beta2gamma1) and laminin-511/521, while alpha7X2beta1 bound preferentially to laminin-111 and laminin-211/221. Laminin-511/521 was the most preferred ligand for all the laminin-binding integrins, except for alpha7X2beta1, whereas laminin-411 was the poorest ligand, capable of binding to alpha6beta1 and alpha7X1beta1 with only modest binding affinities. These comprehensive analyses of the interactions between laminin-binding integrins and a panel of laminins clearly demonstrate that the isoforms of both integrins and laminins differ in their binding specificities and affinities, and provide a molecular basis for better understanding of the adhesive interactions of cells with basement membranes of defined laminin compositions."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2005.12.001"xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Sekiguchi K."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Yagi Y."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Takagi J."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Tsuji T."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Sanzen N."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Nishiuchi R."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/author | "Ido H."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/pages | "189-197"xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/title | "Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins."xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16413178 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16413178 |
| http://purl.uniprot.org/citations/16413178 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16413178 |
| http://purl.uniprot.org/uniprot/#_P11047-mappedCitation-16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16413178 |
| http://purl.uniprot.org/uniprot/#_O15230-mappedCitation-16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16413178 |
| http://purl.uniprot.org/uniprot/#_P24043-mappedCitation-16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16413178 |
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| http://purl.uniprot.org/uniprot/#_Q13683-mappedCitation-16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16413178 |
| http://purl.uniprot.org/uniprot/#_P23229-mappedCitation-16413178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16413178 |