| http://purl.uniprot.org/citations/16415853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16415853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16415853 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosomes interact through their kinetochores with microtubule plus ends and they are segregated to the spindle poles as the kinetochore microtubules shorten during anaphase A of mitosis. The molecular natures and identities of coupling proteins that allow microtubule depolymerization to pull chromosomes to poles during anaphase have long remained elusive. In budding yeast, the ten-protein Dam1 complex is a critical microtubule-binding component of the kinetochore that oligomerizes into a 50-nm ring around a microtubule in vitro. Here we show, with the use of a real-time, two-colour fluorescence microscopy assay, that the ring complex moves processively for several micrometres at the ends of depolymerizing microtubules without detaching from the lattice. Electron microscopic analysis of 'end-on views' revealed a 16-fold symmetry of the kinetochore rings. This out-of-register arrangement with respect to the 13-fold microtubule symmetry is consistent with a sliding mechanism based on an electrostatically coupled ring-microtubule interface. The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04409"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04409"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Barnes G."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Barnes G."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Drubin D.G."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Drubin D.G."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Avila-Sakar A."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Avila-Sakar A."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Wang H.-W."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Wang H.-W."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Westermann S."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/author | "Westermann S."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/pages | "565-569"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/pages | "565-569"xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/title | "The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends."xsd:string |
| http://purl.uniprot.org/citations/16415853 | http://purl.uniprot.org/core/title | "The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends."xsd:string |