| http://purl.uniprot.org/citations/16415884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16415884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16415884 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 x 10(-9)). This was replicated in a Danish cohort (P = 4.8 x 10(-3)) and in a US cohort (P = 3.3 x 10(-9)). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box-containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1732"xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1732"xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Christiansen C."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Christiansen C."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Kong A."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Kong A."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Stefansson H."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Stefansson H."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Stefansson K."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Stefansson K."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Gulcher J.R."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Gulcher J.R."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Magnusson K.P."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Magnusson K.P."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Manolescu A."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Manolescu A."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Saemundsdottir J."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Saemundsdottir J."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Thorleifsson G."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Thorleifsson G."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Thorsteinsdottir U."xsd:string |
| http://purl.uniprot.org/citations/16415884 | http://purl.uniprot.org/core/author | "Thorsteinsdottir U."xsd:string |