| http://purl.uniprot.org/citations/16416090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16416090 | http://www.w3.org/2000/01/rdf-schema#comment | "The quantitative trait locus (QTL) Edpm3 is one of a group of additively acting QTL \responsible for the difference in estrogen-induced pituitary tumor growth between the tumor-susceptible F344 and tumor-resistant BN rat strains. The F344.BN-Edpm3(BN) rat strain was produced by moving the segment of rat Chr 3 between D3Mgh7 and D3Mgh13, which contains the Edpm3 QTL, from the BN strain into the F344 genetic background. In a previous study, we used this congenic line to find that the BN allele of the Edpm3 QTL reduces tissue mass and S-phase fraction in the estrogen-induced rat pituitary tumor. We now report on the use of this congenic line to investigate the linkage of Edpm3 to tumor angiogenesis. Contrary to expectation, the F344.BN-Edpm3(BN) strain has significantly greater angiogenic activity than does F344 in both treated and untreated rats. Microvessel count (MVC), perivascular space, and number of nonattached pericytes/pericapillary fibroblasts are all elevated in the pituitary by chronic estrogen treatment and their values are significantly greater in F344.BN-Edpm3(BN) than F344. Thus, although there is greater angiogenic activity in the pituitary of estrogen-treated F344.BN-Edpm3(BN) rats, there is a deficiency in capillary maturation compared with F344."xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00335-005-2450-4"xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/author | "Wendell D.L."xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/author | "Pandey J."xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/name | "Mamm Genome"xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/title | "Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3."xsd:string |
| http://purl.uniprot.org/citations/16416090 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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