| http://purl.uniprot.org/citations/16420246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16420246 | http://www.w3.org/2000/01/rdf-schema#comment | "Generalized vitiligo is a common autoimmune disorder characterized by white patches of skin and overlying hair caused by loss of pigment-forming melanocytes from involved areas. Familial clustering of vitiligo is not uncommon, and patients and their relatives are at increased risk for a specific complex of other autoimmune diseases. Compared with sporadic vitiligo, familial vitiligo is characterized by earlier disease onset and greater risk and broader repertoire of autoimmunity, suggesting a stronger genetic component, and perhaps stronger associations with specific alleles. To determine whether the major histocompatibility complex (MHC) contributes to the familial clustering of vitiligo and vitiligo-associated autoimmune/autoinflammatory diseases, we performed case-control and family-based association analyses of HLA class II-DRB1 and -DQB1 alleles and haplotypes in affected probands and their parents from 76 European-American Caucasian families with familial vitiligo. Affected probands showed a significantly increased frequency of DRB1*04-DQB1*0301 and a significantly decreased frequency of DRB1*15-DQB1*0602 compared with a large sample of reference chromosomes. Family-based association analyses confirmed these results. Probands with DRB1*04-DQB1*0301 developed vitiligo an average of 13.32 yr earlier than probands with DRB1*15-DQB1*0602. Overall, our results indicate that specific MHC-linked genetic variation contributes to risk of familial vitiligo, although HLA does not completely explain familial clustering of vitiligo-associated autoimmune/autoinflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0749.2005.00279.x"xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/author | "Bennett D.C."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/author | "Spritz R.A."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/author | "Fain P.R."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/author | "Babu S.R."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/name | "Pigment Cell Res"xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/pages | "51-57"xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/title | "HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset."xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/16420246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16420246 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-16420246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16420246 |
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