| http://purl.uniprot.org/citations/16420440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16420440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16420440 | http://www.w3.org/2000/01/rdf-schema#comment | "Anp32e/Cpd1, a member of the acidic nuclear phosphoprotein (Anp)32 family, is characterized by the presence of an amino terminal domain containing four leucine-rich repeats and a carboxyl-terminal low-compositional complexity acidic region. In previous studies performed to understand the biological role of Anp32e/Cpd1, we showed a predominant presence of Anp32e/Cpd1 in the nucleus. However, when Anp32e/Cpd1 is in the cytoplasm, it co-localizes spatially with protein phosphatase 2A (PP2A) near cell membranes, far from the synapses. In the present work, we show that Anp32e/Cpd1 is also present as a membrane-bound 74/76-kDa protein with a widespread distribution in the brain. We reveal that the expression, synthesis and half-life of this high-molecular-weight form of Anp32e/Cpd1 are spatially and temporally correlated with the cerebellar synaptogenesis period. We demonstrate that synaptic Anp32e/Cpd1 co-localizes, interacts and inhibits PP2A activity, and that phosphorylation of Anp32/Cpd1 is required for the Anp32e-PP2A interaction. Also, subcellular localization was shown with electronic microscopy. Finally, we examine Anp32e/Cpd1 and PP2A distribution in two ataxic mutant models, weaver and staggerer, and show that their co-localization in Purkinje cell dendrites depends on parallel fibre/Purkinje cell contacts. Based on these observations, we propose that Anp32e/Cpd1 mediates synaptogenesis process by modulating PP2A activity."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2005.04555.x"xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2005.04555.x"xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Matilla A."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Matilla A."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Radrizzani M."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Radrizzani M."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Carminatti H."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Carminatti H."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Costanzo R.V."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Costanzo R.V."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Perandones C."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Perandones C."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Vila-Ortiz G.J."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/author | "Vila-Ortiz G.J."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/name | "Eur. J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/name | "Eur. J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/pages | "309-324"xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/pages | "309-324"xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/title | "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis."xsd:string |
| http://purl.uniprot.org/citations/16420440 | http://purl.uniprot.org/core/title | "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis."xsd:string |