| http://purl.uniprot.org/citations/16423344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16423344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16423344 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim of the present study was to investigate possible differences between the human dopamine D4 receptor 48 bp polymorphism variants hD4.2, hD.4. and hD4.7 in agonist stimulated [35S]GTPgammaS binding, to investigate dopamine D4 receptor sodium sensitivity and to further characterize norepinephrine and epinephrine agonism at this receptor. G-protein activation at the receptor variants hD4.2, hD4.4 and hD4.7 expressed in CHO-K1 cells, following stimulation by dopamine, norepinephrine and epinephrine, was investigated using the [35S]GTPgammaS assay at experimental conditions of 10 and 100 mM sodium, respectively. Dopamine displayed a 2 fold higher potency of stimulating [35S]GTPgammaS binding at the hD4.2, compared to the hD4.4 and hD4.7 at 10 mM sodium. A significant difference in sodium sensitivity of basal [35S]GTPgammaS binding was found, with the hD4.7 being 1.7 fold more sensitive than the hD4.4 and 2.5 fold more sensitive than the hD4.2. Norepinephrine and epinephrine both produced concentration-dependent increases in [35S]GTPgammaS binding at all three receptor variants, and epinephrine showed only 2 fold less potency than dopamine. The present results are in certain line with previous reports of functional 2-3 fold differences between the dopamine D4 receptor variants. Agonism of norepinephrine and epinephrine at the dopamine D4 receptor may indicate an important way of cross-reactivity among the different monoamine neurotransmitter systems."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2005.11.063"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2005.11.063"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Czermak C."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Czermak C."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Lehofer M."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Lehofer M."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Liebmann P.M."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Liebmann P.M."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Traynor J."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/author | "Traynor J."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/name | "Eur. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/name | "Eur. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/pages | "20-24"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/pages | "20-24"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/title | "[35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/title | "[35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine."xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/volume | "531"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://purl.uniprot.org/core/volume | "531"xsd:string |
| http://purl.uniprot.org/citations/16423344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16423344 |
| http://purl.uniprot.org/citations/16423344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16423344 |