| http://purl.uniprot.org/citations/16423440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16423440 | http://www.w3.org/2000/01/rdf-schema#comment | "The authors investigated the impact of the CYP2D6 genotypes on the plasma concentration of paroxetine (PAX) in 55 Japanese psychiatric patients. They were administered 10 to 40 mg/day (24+/-10.0 mg/day) of PAX and maintained at the same daily dose for at least two weeks to obtain the steady-state concentrations. The plasma levels of PAX were 15.8+/-15.0, 47.4+/-32.0, 101.2+/-59.9 and 177.5+/-123.6 ng/ml at the daily dose of 10, 20, 30 and 40 mg, respectively, which suggested dose dependent kinetics of PAX. The allele frequencies of the CYP2D65, CYP2D610 and CYP2D641 were 1.8%, 41.8% and 1.8%, respectively. Significantly higher PAX concentrations were observed in the patients having one functional allele compared with those with two functional alleles (150.9+/-20.6 vs. 243.6+/-25.2 ng/ml mg(-1) kg(-1), p<0.05, Newman-Keuls multiple comparison test) or no functional (243.6+/-25.2 vs. 76.7+/-6.1 ng/ml mg(-1) kg(-1), p<0.05, Newman-Keuls multiple comparison test) in the subjects with 30 mg/day of paroxetine. The same trend of findings as in the subjects treated with 30 mg/day were observed in the subjects with 40 mg/day of PAX. The present results suggest that having one non-functional allele is the marker for high plasma concentration of PAX when relatively high daily dose of PAX is administered."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pnpbp.2005.11.007"xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Akiyama K."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Ueda M."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Morita S."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Shimoda K."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Okawa M."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/author | "Hirokane G."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/name | "Prog Neuropsychopharmacol Biol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/pages | "486-491"xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/title | "The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients."xsd:string |
| http://purl.uniprot.org/citations/16423440 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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