| http://purl.uniprot.org/citations/16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16424186 | http://www.w3.org/2000/01/rdf-schema#comment | "Itk and Rlk are members of the Tec kinase family of nonreceptor protein tyrosine kinases that are expressed in T cells, NK cells, and mast cells. These proteins are involved in the regulation of signaling processes downstream of the TCR in CD4(+) T cells, particularly in the phosphorylation of phospholipase C-gamma1 after TCR activation; furthermore, both Itk and Rlk are important in CD4(+) T cell development, differentiation, function, and homeostasis. However, few studies have addressed the roles of these kinases in CD8(+) T cell signaling and function. Using Itk(-/-) and Itk(-/-)Rlk(-/-) mice, we examined the roles of these Tec family kinases in CD8(+) T cells, both in vitro and in vivo. These studies demonstrate that the loss of Itk and Rlk impairs TCR-dependent signaling, causing defects in phospholipase C-gamma1, p38, and ERK activation as well as defects in calcium flux and cytokine production in vitro and expansion and effector cytokine production by CD8(+) T cells in response to viral infection. These defects cannot be rescued by providing virus-specific CD4(+) T cell help, thereby substantiating the important role of Tec kinases in CD8(+) T cell signaling."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.3.1571"xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/author | "Berg L.J."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/author | "Brehm M.A."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/author | "Welsh R.M."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/author | "Atherly L.O."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/pages | "1571-1581"xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/title | "Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help."xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16424186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16424186 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JG94-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV29-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
| http://purl.uniprot.org/uniprot/#_Q0VBP6-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1V5-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
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| http://purl.uniprot.org/uniprot/#_D6RJM5-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
| http://purl.uniprot.org/uniprot/#_P42682-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |
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| http://purl.uniprot.org/uniprot/#_I6L9F0-mappedCitation-16424186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16424186 |