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| http://purl.uniprot.org/citations/16424299 | http://www.w3.org/2000/01/rdf-schema#comment | "Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is phosphorylated on only one of two key residues in the activation loop. Unexpectedly, at a systems level, autoactivated Fus3 appears to have a negative regulatory role, promoting Ste5 phosphorylation and a decrease in pathway transcriptional output. Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1120941"xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Bhattacharyya R.P."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Lim W.A."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Bashor C.J."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Remenyi A."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Falick A.M."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/author | "Good M.C."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/pages | "822-826"xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/title | "The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway."xsd:string |
| http://purl.uniprot.org/citations/16424299 | http://purl.uniprot.org/core/volume | "311"xsd:string |
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