| http://purl.uniprot.org/citations/16428298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16428298 | http://www.w3.org/2000/01/rdf-schema#comment | "KLHY is a short amino-acid sequence of inhibitor-2. This sequence is highly conserved with the protein phosphatase 1 (PP1)-binding consensus motif, RVXF. The role of this segment in binding with PP1 is ambiguous. By using surface plasmon resonance we have characterized its binding ability to PP1. Either site-directed mutagenesis or deletion of KLHY did not significantly affect the dissociation constant between PP1 and inhibitor-2. In comparison with DARPP-32, the deletion of KKIQF, a PP1-binding motif of DARPP-32, resulted in a remarkable reduction in its affinity with PP1. Our results suggested that, compared with the common RVXF motif, the KLHY sequence in intact inhibitor-2 binds weakly to PP1."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvi167"xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Chen Y.C."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Wang L.H."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Lin T.H."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Tsai P.C."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Liu H.T."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Huang H.B."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/author | "Hsieh F.K."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/pages | "697-700"xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/title | "Characterization of the protein phosphatase 1-binding motifs of inhibitor-2 and DARPP-32 by surface plasmon resonance."xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/16428298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16428298 |
| http://purl.uniprot.org/citations/16428298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16428298 |
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