| http://purl.uniprot.org/citations/16428445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16428445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16428445 | http://www.w3.org/2000/01/rdf-schema#comment | "h-prune, which has been suggested to be involved in cell migration, was identified as a glycogen synthase kinase 3 (GSK-3)-binding protein. Treatment of cultured cells with GSK-3 inhibitors or small interfering RNA (siRNA) for GSK-3 and h-prune inhibited their motility. The kinase activity of GSK-3 was required for the interaction of GSK-3 with h-prune. h-prune was localized to focal adhesions, and the siRNA for GSK-3 or h-prune delayed the disassembly of paxillin. The tyrosine phosphorylation of focal adhesion kinase (FAK) and the activation of Rac were suppressed in GSK-3 or h-prune knocked-down cells. GSK-3 inhibitors suppressed the disassembly of paxillin and the activation of FAK and Rac. Furthermore, h-prune was highly expressed in colorectal and pancreatic cancers, and the positivity of the h-prune expression was correlated with tumor invasion. These results suggest that GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.3.898-911.2006"xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.3.898-911.2006"xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Hino S."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Hino S."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Zollo M."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Zollo M."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Asahara T."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Asahara T."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Yasui W."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Yasui W."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Oue N."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/author | "Oue N."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/pages | "898-911"xsd:string |
| http://purl.uniprot.org/citations/16428445 | http://purl.uniprot.org/core/pages | "898-911"xsd:string |