http://purl.uniprot.org/citations/16429139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16429139 | http://www.w3.org/2000/01/rdf-schema#comment | "The B-1 subpopulation of B lymphocytes differs phenotypically and functionally from conventional B-2 B cells. B-1 B cells are proposed to derive from a distinct progenitor, but such a population has not been isolated. Here we identify and characterize a B-1 B cell progenitor whose numbers peaked in fetal bone marrow but were less abundant in postnatal bone marrow. These Lin(-)CD45R(lo-neg)CD19(+) cells responded to thymic stromal lymphopoietin and 'preferentially' reconstituted functional sIgM(hi)CD11b(+)CD5(lo-neg) B-1 B cells, but not sIgM(+)CD11b(-) B-2 B cells, in vivo. These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells."xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1301"xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/author | "Montecino-Rodriguez E."xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/author | "Dorshkind K."xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/author | "Leathers H."xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/pages | "293-301"xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/title | "Identification of a B-1 B cell-specified progenitor."xsd:string |
http://purl.uniprot.org/citations/16429139 | http://purl.uniprot.org/core/volume | "7"xsd:string |
http://purl.uniprot.org/citations/16429139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16429139 |
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