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| http://purl.uniprot.org/citations/16432184 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetically primed adult C57BL mice were deleted of exon 5 of the gene encoding the transcription factor PU.1 by IFN activation of Cre recombinase. After a 13-week delay, conditionally deleted (PU.1(-/-)) mice began dying of myeloid leukemia, and 95% of the mice surviving from early postinduction death developed transplantable myeloid leukemia whose cells were deleted of PU.1 and uniformly Gr-1 positive. The leukemic cells formed autonomous colonies in semisolid culture with varying clonal efficiency, but colony formation was enhanced by IL-3 and sometimes by granulocyte-macrophage colony-stimulating factor. Nine of 13 tumors analyzed had developed a capacity for autocrine IL-3 or granulocyte-macrophage colony-stimulating factor production, and there was evidence of rearrangement of the IL-3 gene. Acquisition of autocrine growth-factor production and autonomous growth appeared to be major events in the transformation of conditionally deleted PU.1(-/-) cells to fully developed myeloid leukemic populations."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0510616103"xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Metcalf D."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Mifsud S."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Di Rago L."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Nutt S."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/author | "Dakic A."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/pages | "1486-1491"xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/title | "Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/16432184 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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