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| http://purl.uniprot.org/citations/16434054 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53-inducible protein PIDD, the adapter protein RAIDD and caspase-2. RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2 and a C-terminal death domain (DD) that interacts with the DD in PIDD. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, we report the crystal structure of RAIDD DD at 2.0 A resolution. The high-resolution structure reveals important features of RAIDD DD that may be important for DD folding and dynamics and for assembly of the PIDDosome."xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2005.12.082"xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/author | "Park H.H."xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/pages | "358-364"xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/title | "Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly."xsd:string |
| http://purl.uniprot.org/citations/16434054 | http://purl.uniprot.org/core/volume | "357"xsd:string |
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