| http://purl.uniprot.org/citations/16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16434964 | http://www.w3.org/2000/01/rdf-schema#comment | "The promyelocytic leukemia (PML) gene codes for a tumor suppressor protein that is associated with distinct subnuclear macromolecular structures called the PML bodies. The PML gene is frequently involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL). The translocation results in a fusion gene product, PML-RARalpha, in which the PML gene fuses to the retinoic acid receptor alpha (RARalpha) gene. PML-RARalpha has been shown to promote transcriptional repression of genes involved in myeloid terminal differentiation and to disrupt the architecture of PML bodies, a phenotype reversed by treatment with all trans retinoic acid (ATRA). However, there are several alternatively spliced isoforms of PML-RARalpha. Here, we addressed the differences between the short and the long isoforms of PML-RARalpha (L and S) since both are associated with APL. We demonstrate that PML-RARalphaL, but not PML-RARalphaS, can directly promote cell growth by transcriptionally activating the pro-proliferative gene, c-fos, in response to mitogenic stimulation. The activity of the PML-RARalphaL is completely sensitive to ATRA. We further show that this activation is not via direct recruitment of the protein to the c-fos promoter but indirectly by altering the chromosomal environment of the c-fos gene, thereby rendering it more accessible to the signal induced transcriptional activators. Our results suggest that in addition to antagonizing the PML-tumor suppressor or the PML-pro-apoptotic activity, PML-RARalpha proteins can also directly promote cell growth by activating c-fos."xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209388"xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/author | "Roy A.L."xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/author | "Tussie-Luna M.I."xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/author | "Rozo L."xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/pages | "3375-3386"xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/title | "Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia."xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16434964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16434964 |
| http://purl.uniprot.org/citations/16434964 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16434964 |
| http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_D3Z3A6-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q4FK21-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q8BSJ6-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_P01101-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_O89066-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_P11416-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q3U463-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q3U3R3-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q3U5E7-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q5BLJ8-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |
| http://purl.uniprot.org/uniprot/#_Q60953-mappedCitation-16434964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16434964 |