| http://purl.uniprot.org/citations/16438969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16438969 | http://www.w3.org/2000/01/rdf-schema#comment | "The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosolic selenoprotein TrxR-1. In situ hybridization experiments demonstrates high expression of Txl-1 mRNA in various areas of central nervous system and also in some reproductive organs. Glucose deprivation, but not hydrogen peroxide treatment, reduced the levels of endogenous TXL-1 protein in HEK-293 cell line. Conversely, overexpression of TXL-1 protects against glucose deprivation-induced cytotoxicity. Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.01.025"xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/author | "Jimenez A."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/author | "Pelto-Huikko M."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/author | "Miranda-Vizuete A."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/pages | "960-967"xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/title | "Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation."xsd:string |
| http://purl.uniprot.org/citations/16438969 | http://purl.uniprot.org/core/volume | "580"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A494BB31-mappedCitation-16438969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16438969 |
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